


Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a fast-progressing and ultimately fatal neurological condition. It affects the nerve cells (neurons) that control voluntary muscle movements, such as walking, speaking, and breathing. While there is currently no cure, about 10% of people diagnosed with ALS live 10 years or longer after the onset of symptoms.
Project Main Street provides support for individuals afflicted with Amyotrophic Lateral Sclerosis (ALS) and their families by reducing the financial burden associated with the disease.
Marquee Sports Network and the Chicago Cubs have teamed up to host the fifth annual Lou Gehrig Day Auction benefiting Project Main Street and the fight to end ALS.
Bid on once-in-a-lifetime experiences and memorabilia, including the opportunity to call play-by-play on Marquee, shadow Marquee on-air talent, score a VIP studio & broadcast booth tour, and more!
🗓️ Auction ends Sunday, June 22 at 8 PM CT!
We’re highlighting the stories of Cubs fans impacted by ALS to help raise awareness and support their fight.
In The News

The Mission
Project Main Street strives to improve the quality of life for people afflicted with ALS. The organization helps both low income and middle income individuals and families. Project Main Street is committed to helping those who are experiencing financial challenges as a direct result of ALS (Lou Gehrig’s Disease).
How To Help
Project Main Street is a non-profit, volunteer organization that relies on private donations to enable us to help those in need. Project Main Street is a 501(c)(3) non-profit organization and all donations are tax-deductible.
Request Help
Are you or someone you know under financial burden as a result of ALS? Project Main Street may be able to help. Contact them today in order find out the next steps.













